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 57 Synttrirciecrer® ist ein ß-Tricreaplcreiusemntpshosa- treatment of surgical bone defects or defects of
 Bone and Joint Reconspthraut icntreioinenr Form. another pathogenesis:
pure ß‐tricalcium phosphate biomaterial.
Synthacer® and Syntricer® ImpB–laaBseondntesovnoidth el‐lincgurorfednet Hfelicyttesdracrtauoursxee,ydapbuyprtearatßui‐mteatand
Was war das Problem der TCP
– Filling of bone voids a er gathering of autolo- tricalcium phosphates failed to succeed in
ß‐Tricalciumphosphate
Werkstoffe, dass sie sich nicht gous cancellous bone, i.e. the iliac crest or do-
both dental applications and orthopaedics.
76
76
REV011
57
nor regi eDnednutraelbae Syntrhiacc
58
und in 58 idninemoovnanot
76
Synthacer® and Syntricer® are indicated for the
Tdhunerocbrhiodsmeftaeztcetsrniainlsthwkeoenrternontceohntle,satrpoanwtgeeleldaneorourghoitmthoer do-
Syntri
pätdreiea?tm
pure ß‐t
phat i (Fifga.cia5l7s)u.
Stanboiltihtäet
materials
di–esBeomne Based p“Crolipneicratilees
Was bit–prhicFailslcisniuc tprriocaplecriu mes
®
 a–chBioenve vo
Werks rz–aubtBiobgntnrhoeiunvdsgo
hw–yTdedOhlrusconetrhxeocybeorahcsiopdos
w–itRhasndtoaionrpdras cheDenemdnuistrcael
T–CBPiocroem – Bone achieve
Solche pädie?
b–ipPhuarsiticy op
facial (Fig. 5
jedoch k prSedtaicbtaiblil
materia vom Kö Only Syntr
diese
“Clinica
proper®t Sb- yenhterianicrdelyrerc
biphas
tprriocaplecriu idninemoovnanotirhvmse
 rerz–paurteBisoebnrteis herstellt.
tOrinh–clayldOcSriysuontmxetyh welch Syntricer
r–e–asblosRwoard(binie withsta chemi
phat in r
uptake, it T–CBPiocroe
neSroHlcehrse nUepwulyn‐ folrt b–ipPhuarsiti
sactnjadefbfdSoiyloedn.csthI predict a1can0li0md%eavlicerexes
vom Only Sy
Tohfethresduirlet schnell v Sb- yenhterianicrel resorption
modellin Figr.e5p9re(rsieg herste
physiolo c a On cnel lyl o Suys tricalciu
Syntri
rgeswiduaendoef r–easbloswor
pArbpobcheialsdstuisni uptake,
raHrce wulyn‐ f
Synthacer® and Syntricer® are indicgaitnoeseda nUep
 for the treatment of surgical bonevodsntea- sacna
imcaPlr fects or defects of another pathogenesainsi:
To hf e t – Bone void  lling of defects caused by
traumata
– Filling of bone voids a er gathering of m
autologous cancellous bone, i.e. the ili- ph can
ac crest or donor defects in the troch-
lea patellae or other donor regions.rgesi pro Ab
– Bone void  lling and augmenta on in
maxilla-facial surgery.
“Clinical evidence con rms the following product proper es”:
– Bone void  lling
– Osteoconduc on
– Radiopaque material – Biocompa bility
– Purity of the material.
10
sc
res un
Fig.
gio vo im
TCP- df bf Soi yl l edn
mdoeazveli 0%
hresd hnel
orpti di
odel 59 (
ysio cell
wduaen
cess bild
saa n TC Pro
sre® oicshteocnoncdhuctivne dmearterOiarlsthoto-
er® and Syn®tricer® are indicated for the Orenr®ly Syisnttreiciner®ß:-Tricreaplcreiusemntpshosa-
Syntricer represents a iodn ellinhgeanlidngaugamsendtoac uomneintemdaxilla-
 nDtaosf suPrgoibcalelmbonewdaerfectihsroer defects of
ricalcium phosphate biomaterial.
– nearly complete biodegrada on within 3 – 4 repiunrerßF‐otrimca.lcium phosphate biomaterial.
rgeArsy. a consequence, biphasic
, pwatiheogliennkessisd:argestellt. Aus
wemre ointrhodsudcedpecnomdibninginugptohne the turn-over rate
vruonidd ellhinagttoef dmeafenctbsecgaounsneednb,y traumata on the current literature, pure ß‐
oidfehnycderocxoyna pramtitsetwheithfotlhlowseinogf pßr‐oduct
waBrasedasonPrtohbelemcurrednetr liTteCrPature, pure ß‐
hmoefpPbhronsdpeuhkvatoteidssaufaf ileddrengtaoMthseaurciknctegeodf ianutolo- ”O:pnhloyspShyantethadecpeern®d:ing on the
toftfreic,alcdiuamss phsoiesphsaitcehs faniilcehdt to succeed in oeicdnfnat nalcl–lienHaglmlpAop/uißtlsi‐cTaAbCtoPni.onteneis,leiTa.nhene.dvthoenrstithlaHioabAcple,aceredsictso. r do-
– slow (insigni cant) biodegrada on amenetndfitaetibuzectceoeht isrntoihaninlerseatdhrwkseloyeoenrnrtbteronaoinenltc‐reorhteantlsepo,sawptrrbpiloraiacdnwbtagletluelidaonenodrousrgahointmthoderodrot-hopaedics.
queearmlyatdeerigarladation, whereas ß‐
giTohnse. biomaterials were not strong enough to
Ubuaepnsrdeuoinpcsh htyelsotiocnkoadonlacidsyhcu,hcntsiovntaeibnidtlmeisartat.ecr Oiaorlstnhbotoe-tween Syntricer®
ian sbiliftuylly reabsorbable. Those
void  lling and augmenta on in maxilla-
bone healing as documented
ipehansdisucrhee aPrsodouskteolcaosnsednuctive materials to
andDSaysnthaPcreorb®lepmroduwctasrandihdreugs or other medi- rothdeucmtsataereia,l.however, no longer
surgery.
7). As a consequence, biphasic
ine Aussage mehr zu, wie sie cäatal,cdhweiveiievcelsinhkbasosnbdeaerngheoesbtaesleilnlrtgv.eAda,uwsithdothceumexecnetpe don
with respect to its resorption.
ls were introduced combining the per abgebaut werden. Sie
ice(rF®:ig. 57). As a consequence, biphasic of the direct combina on with s   implants.
Grunde hatte man begonnen,
l evidence con rms the following product ies of hydroxyapatite with those of ß‐ nomdp‐alesteRebimboadosedegderaldlian go,onnwweiltchhinaens3 – 4
materials were introduced combining the ische Produkte auf den Markt
mes”:phosphate depending on the depemnadninugfaucptuornintghe turtnec-ohvneorloragtye
ale Knochenstruktur wieder-
properties of hydroxyapatite with those of ß‐
nSvygooneidftnr ilcl–ienHrgm®A/rißet‐pTArCePns.teniltesTnhaepvuornestßaH-btAlre,icalcium phospha-
a very strong and pure ß‐
tricalcium phosphate depending on the pachpcoeoanrst®dpit:uheact ieson(nFeiga.r5ly8)nwonh‐icrheswoirllbbaeble and
tse bnioicmhatterreiasol.rbiert wird ® – ein ß-Tricalciumphos-
und
igunpi ctaont1)0b0i%od.eDguraedat ooints water npdasrqauteeiaormnlyatdeerigaorlafdatioHn,A/wßh‐eTrCeaP.s ß‐ The stable
ch und physikalisch stabil ist. einer Form, ist aufgrund sei-
will rapidly be overgrown by Bmapasiaen sdbioliftnuylltyherecaubrsroernbtablilte.ratTuhroes,e pure ß-tricalcium
hydroxyapatite is nearly non‐resorbable and
elbluipnhgsatseicshcnhoelogPireoedinukhtoech-lassen deady,bnooneinitnecroacrp ornatbinegtwtehenßS‐TyCnPtricer®
opfrothdeucmtsataereia,l.however, no longer
phosphates failed to succeed in both dental appli-
withstands early degradation, whereas ß‐ tsck-eTerCe®insPpoeroIpmAdtiupoucnlstasniastngadetv,damrlwugaestlhecodrhr oezintsuh,ezarwunmiedsi-ie
ble with respect to its resorption.
ca ons and orthopaedics. The biomaterials were sehoraTrismbCbiePenretnorownebismdredorag.vsienEdas,nwdwitpfhiurutdblhllyeisheexhcdrere. pa bosnorbable. Those
örper abgebaut werden. Sie ntricer®:
cnwtoactsomdsetbrsincorani bgoednewansiotahusg reh mitmoodpeleallnintdgs‐.ure as osteoconduc ve onbKipnhoachseicnzperlloednukcotlsonaisrie,rthowever, no longer
®
yrercnomdp‐alesteRebimboadosedegderaldlian go,onnwweiltchhinaens3 – 4
process Draenert et al. 2013. meaintermialsktomapclihziervtenbonRe-healing as documented
predictable with respect to its resorption. ihvse depemnadninugfaucptuornintghe turtnec-ohvneorloragtye
rmale Knochenstruktur wieder-
g(F-Rige.so5r7p)t.ionAspraozceossnsineqeuineence, biphasic materials
hnt)s Coampvlerteyly stronrgestaruncdturepdure ß‐ llt.
ische Knoch®enstruktur um-
were introduced combining the proper es of hy-
nmtbhSopaynhcneotrsr®psi:chaeaftrfoeld(Figw.it5‐h8) inwchluidchbedawsielldbe on
an
er® – ein ß-Tricalciumphos- ßlt‐.TCP. The remodelling resorption
(bdineriodsnixgnuynopai vpctaot nivt1t)e0b0wi%oid.tehDmgturhaedonatsu oefoaointcfstußwr-tainrtiegcralciutmecphhnoslpohgayte
sgt:irlleWoini‐egedorienFrgho. errmge,sitsetlltaeufSgproun-d sei-
dietpewnildlinragpiodnlythberoav eorgnroowfnHAby/ß-TCP.Thestable represents a very strong and pure ß‐
r i t s e t k e t l u l u r n mg s i t t e c k h l e n i n o e l o n g i R e e s e t i e n n h o c h - olrtmodeady,bnooneinitnecroacrp ornatbinegtwtehenßS‐TyCnPtricer®
hydroxyapa te is nearly non-resorbable and with- tricalcium phosphate (Fig. 58) which will be
Einschlüssen, die aber weiter .sthIaßtsc-eTrCe®sPporoIpmdtiupocnltasniastnadetv,darlwugaestlecodhr oeintshezarunmedi-
stands early degrada on, whereas ß-TCP remains reabsorbed up to 100%. Due to its water
scsesdehrasRbeesoernpotibosnersvined,. with the excep on experiment on dogs and published. resorbiert wird. Es wird sehr
fuullyptraekaeb,soitrbawbilel. rTahpoidselybibpehasoivceprgrorodwucntsbayre,
uirlet cwt acsomdebsincrai boedn wasitha s re mimodpelallnintgs‐.
l von Knochenzellen kolonisiert honweewvleyr‐,fonromloendgberonpereidnictoarbploerwatiitnhgrethspeeßc‐tTtCoPits
on process Draenert et al. 2013.
n einem komplizierten Re-
rescoarpff ooldn.. Its resorption is evaluated in an
ling-Resorptionsprozess in eine rigahnt)imCaolmepxleptelryimentreosntrudctougresdand published.
Syntricer® – based on an innova ve manufactu- logische Knochenstruktur um-
us bone scaffold with included
The result was described as a remodelling‐
ring technology represents a very strong and pure doef ßlt‐.TCP. The remodelling resorption
resorption process Draenert et al. 2013.
ß-tricalcium phosphate (Fig. 58) which will be re- is still on‐going.
ung: Wiederhergestellte Spon-
absorbed up to 100%. Due to its water uptake, it rchitektur mit kleinen Resten
Fig. 59 (right) Completely restructured
will rapidly be overgrown by newly-formed bone P-Einschlüssen, die aber weiter
cancellous bone scaffold with included
incorpora ng the ß-TCP sca old. Its resorp on is zess der Resorption sind.
residue of ß‐TCP. The remodelling resorption evaluated in an animal experiment on dogs and
process is still on‐going.
published. The result was described as a remodel-
ling-resorp on process [Draenert et al. 2013].
Fig. 59 (right) Completely restructured cancellous bone sca old with included residue of ß-TCP. The remodelling resorp on process is s ll on-going.
6112017EN
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